InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAPGEF1

Summary

InnateDB Gene

IDBG-90109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF1

Gene Name

Rap guanine nucleotide exchange factor (GEF) 1

Synonyms

C3G; GRF2

Species

Homo sapiens

Ensembl Gene

ENSG00000107263

Encoded Proteins

IDBP-90111

Rap guanine nucleotide exchange factor (GEF) 1

IDBP-90121

Rap guanine nucleotide exchange factor (GEF) 1

IDBP-90123

Rap guanine nucleotide exchange factor (GEF) 1

IDBP-382997

Rap guanine nucleotide exchange factor (GEF) 1

IDBP-382998

Rap guanine nucleotide exchange factor (GEF) 1

IDBP-382999

Rap guanine nucleotide exchange factor (GEF) 1

IDBP-383001

Rap guanine nucleotide exchange factor (GEF) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:131576770-131740074

Strand

Reverse strand

Band

q34.13

Transcripts

ENST00000372195	ENSP00000361269
ENST00000372190	ENSP00000361264
ENST00000372189	ENSP00000361263
ENST00000414781	ENSP00000407210
ENST00000419442	ENSP00000394296
ENST00000438647	ENSP00000410640
ENST00000427994	ENSP00000402174
ENST00000481260

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001568	blood vessel development
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0016337	single organismal cell-cell adhesion
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051898	negative regulation of protein kinase B signaling
GO:0061028	establishment of endothelial barrier
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000178	negative regulation of neural precursor cell proliferation