InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GIT2

Summary

InnateDB Protein

IDBP-383093.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIT2

Protein Name

G protein-coupled receptor kinase interacting ArfGAP 2

Synonyms

CAT-2; CAT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000391813

InnateDB Gene

IDBG-56520 (GIT2)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for the ADP ribosylation factor family.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005654

nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein
IPR002110 Ankyrin repeat
IPR013724 Spa2 homology (SHD) of GIT
IPR020683 Ankyrin repeat-containing domain
IPR022018 G protein-coupled receptor kinase-interacting protein 1 C term

PFAM