Homo sapiens Gene: GIT2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-56520.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | GIT2 | ||||||||||||||||||||||
Gene Name | G protein-coupled receptor kinase interacting ArfGAP 2 | ||||||||||||||||||||||
Synonyms | CAT-2; CAT2 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000139436 | ||||||||||||||||||||||
Encoded Proteins |
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
G protein-coupled receptor kinase interacting ArfGAP 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:109929792-109996389 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q24.11 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TCR pathway
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REACTOME | |||||||||||||||||||||||
KEGG |
Endocytosis pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Signaling events mediated by focal adhesion kinase
Integrin-linked kinase signaling
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.434996 Hs.686678 | ||||||||||||||||||||||
RefSeq | NM_001135213 NM_001135214 NM_014776 NM_057169 NM_057170 NM_139201 XM_005253997 XM_006719714 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS44968 CCDS44969 CCDS55884 CCDS9138 CCDS9139 | ||||||||||||||||||||||
HPRD | 09779 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||