Version 5.4
Homo sapiens Protein: GAL3ST4
Summary
InnateDB Protein IDBP-383299.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAL3ST4
Protein Name galactose-3-O-sulfotransferase 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400451
InnateDB Gene IDBG-30821 (GAL3ST4)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc. {ECO:0000269PubMed:11333265}.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed mainly in placenta, thymus, testis, ovary, spinal cord, trachea and adrenal gland and at low levels in brain, lung, spleen, prostate, small intestine, colon, stomach thyroid and lymph node. {ECO:0000269PubMed:11333265}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001733 galactosylceramide sulfotransferase activity
GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050694 galactose 3-O-sulfotransferase activity
GO:0050698 proteoglycan sulfotransferase activity
Biological Process
GO:0006790 sulfur compound metabolic process
GO:0007267 cell-cell signaling
GO:0009058 biosynthetic process
GO:0009100 glycoprotein metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0030166 proteoglycan biosynthetic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009729 Galactose-3-O-sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF06990
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RP7
PhosphoSite PhosphoSite-Q96RP7
TrEMBL
UniProt Splice Variant
Entrez Gene 79690
UniGene Hs.44856
RefSeq
HUGO HGNC:24145
OMIM 608235
CCDS CCDS5688
HPRD 12195
IMGT
EMBL AF289575 AF316113 AK022178 AL833824 BC012976 CH236956 CH471091
GenPept AAH12976 AAK73365 AAL55759 BAB13977 CAD38686 EAL23847 EAW76575 EAW76577 EAW76579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca