InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAG3

Summary

InnateDB Protein

IDBP-383363.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAG3

Protein Name

stromal antigen 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000400359

InnateDB Gene

IDBG-30896 (STAG3)

Protein Structure

UniProt Annotation

Function

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00750, ECO:0000269PubMed:12034751}. Chromosome {ECO:0000269PubMed:12034751}. Chromosome, centromere {ECO:0000269PubMed:12034751}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation.

Disease Associations

Tissue Specificity

Testis specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding

Biological Process

GO:0007059	chromosome segregation
GO:0007130	synaptonemal complex assembly

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000795	synaptonemal complex
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0030893	meiotic cohesin complex