InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FKBP8

Summary

InnateDB Protein

IDBP-38338.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBP8

Protein Name

FK506 binding protein 8, 38kDa

Synonyms

FKBP38; FKBPr38;

Species

Homo sapiens

Ensembl Protein

ENSP00000222308

InnateDB Gene

IDBG-38336 (FKBP8)

Protein Structure

UniProt Annotation

Function

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269PubMed:12510191, ECO:0000269PubMed:15757646, ECO:0000269PubMed:16176796}.

Subcellular Localization

Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.Isoform 3: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. {ECO:0000269PubMed:18385096}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.

Experimentally validated
Total	99 [view]
Protein-Protein	99 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0006915	apoptotic process
GO:0016032	viral process
GO:0035556	intracellular signal transduction
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00254
PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14318