InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3R3

Summary

InnateDB Protein

IDBP-383386.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3R3

Protein Name

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

Synonyms

p55; p55-GAMMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000391431

InnateDB Gene

IDBG-98070 (PIK3R3)

Protein Structure

UniProt Annotation

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Subcellular Localization

Disease Associations

Tissue Specificity

Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	64 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0035014	phosphatidylinositol 3-kinase regulator activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008286	insulin receptor signaling pathway
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0044281	small molecule metabolic process