InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ERN1

Summary

InnateDB Protein

IDBP-383434.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERN1

Protein Name

endoplasmic reticulum to nucleus signaling 1

Synonyms

hIRE1p; IRE1; IRE1a; IRE1P;

Species

Homo sapiens

Ensembl Protein

ENSP00000401445

InnateDB Gene

IDBG-64539 (ERN1)

Protein Structure

UniProt Annotation

Function

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. {ECO:0000250UniProtKB:Q9EQY0, ECO:0000269PubMed:11175748, ECO:0000269PubMed:12637535, ECO:0000269PubMed:9637683}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269PubMed:9637683}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269PubMed:9637683}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004519	endonuclease activity
GO:0004521	endoribonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0070055	HAC1-type intron splice site recognition and cleavage
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response

Cellular Component

GO:0005637	nuclear inner membrane
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006567 PUG domain
IPR010513 KEN domain
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06479

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00580
SM00564
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt