InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX5

Summary

InnateDB Protein

IDBP-383455.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX5

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

Synonyms

G17P1; HLR1; HUMP68; p68;

Species

Homo sapiens

Ensembl Protein

ENSP00000403085

InnateDB Gene

IDBG-64774 (DDX5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 230 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	230 [view]
Protein-Protein	221 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003712	transcription cofactor activity
GO:0003724	RNA helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Biological Process

GO:0006200	ATP catabolic process
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR012587 P68HR
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF08061

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite