InnateDB Protein
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IDBP-383498.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TRAFD1
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Protein Name
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TRAF-type zinc finger domain containing 1
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Synonyms
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FLN29;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000396526
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InnateDB Gene
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IDBG-57921 (TRAFD1)
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Protein Structure
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Function |
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0045087
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innate immune response (InnateDB)
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GO:0045824
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negative regulation of innate immune response
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Cellular Component |
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PDB ID |
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InterPro |
IPR008974
TRAF-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14545
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PhosphoSite |
PhosphoSite-O14545
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TrEMBL |
S4R2Z9
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UniProt Splice Variant |
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Entrez Gene |
10906
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UniGene |
Hs.618023
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RefSeq |
NP_006691
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HUGO |
HGNC:24808
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OMIM |
613197
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CCDS |
CCDS9160
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HPRD |
10994
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IMGT |
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EMBL |
AB007447
AC073575
AK291331
BC003553
CH471054
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GenPept |
AAH03553
BAA22541
BAF84020
EAW97995
EAW97996
EAW97997
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