Version 5.4
Homo sapiens Gene: TRAFD1
Summary
InnateDB Gene IDBG-57921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAFD1
Gene Name TRAF-type zinc finger domain containing 1
Synonyms FLN29
Species Homo sapiens
Ensembl Gene ENSG00000135148
Encoded Proteins
IDBP-57923
TRAF-type zinc finger domain containing 1
IDBP-383498
TRAF-type zinc finger domain containing 1
IDBP-583586
TRAF-type zinc finger domain containing 1
IDBP-595305
TRAF-type zinc finger domain containing 1
IDBP-813735
TRAF-type zinc finger domain containing 1
IDBP-595764
TRAF-type zinc finger domain containing 1
IDBP-584311
TRAF-type zinc finger domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18849341
TRAFD1 deficiency reveals its negative regulatory role in the TLR and RIG-I-like helicases signalling pathway and was found to interact with TRIF, IPS-1, TRAF3 and TRAF6 in mice
PMID 16221674
TRAFD1 is an interferon and LPS inducible gene acting as a negative regulator of Toll-like receptor signalling.
Entrez Gene
Summary The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112125501-112153609
Strand Forward strand
Band q24.13
Transcripts
ENST00000257604 ENSP00000257604
ENST00000412615 ENSP00000396526
ENST00000550051
ENST00000549358 ENSP00000449319
ENST00000547063 ENSP00000449297
ENST00000548092 ENSP00000473800
ENST00000552890 ENSP00000447340
ENST00000552896 ENSP00000450357
ENST00000548277
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0034097 response to cytokine
GO:0045087 innate immune response (InnateDB)
GO:0045824 negative regulation of innate immune response
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042726
View Gene Order
ENSBTAG00000008761
Not yet available
Cross-References
SwissProt
TrEMBL F8VWK2
UniProt Splice Variant
Entrez Gene 10906
UniGene Hs.5148 Hs.618023
RefSeq NM_001143906 NM_006700
HUGO HGNC:24808
OMIM 613197
CCDS CCDS9160
HPRD 10994
IMGT
EMBL AC073575
GenPept
RNA Seq Atlas 10906

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca