InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNA13

Summary

InnateDB Protein

IDBP-383509.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNA13

Protein Name

guanine nucleotide binding protein (G protein), alpha 13

Synonyms

G13;

Species

Homo sapiens

Ensembl Protein

ENSP00000400717

InnateDB Gene

IDBG-64978 (GNA13)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subcellular Localization

Membrane; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages. In round spermatids, also present in the nuclei.

Disease Associations

Tissue Specificity

Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level). {ECO:0000269PubMed:18703424}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031702	type 1 angiotensin receptor binding
GO:0031752	D5 dopamine receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001701	in utero embryonic development
GO:0006184	GTP catabolic process
GO:0006928	cellular component movement
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007266	Rho protein signal transduction
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0030334	regulation of cell migration
GO:0031584	activation of phospholipase D activity
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031526	brush border membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000469 G-protein alpha subunit, group 12
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00440
PR00318
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt