InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP62

Summary

InnateDB Protein

IDBP-383583.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP62

Protein Name

nucleoporin 62kDa

Synonyms

IBSN; p62; SNDI;

Species

Homo sapiens

Ensembl Protein

ENSP00000407331

InnateDB Gene

IDBG-246910 (NUP62)

Protein Structure

UniProt Annotation

Function

Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.

Subcellular Localization

Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle.

Disease Associations

Infantile striatonigral degeneration (SNDI) [MIM:271930]: Neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and mental retardation. {ECO:0000269PubMed:16786527}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	77 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore
GO:0030159	receptor signaling complex scaffold activity
GO:0042169	SH2 domain binding
GO:0043130	ubiquitin binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006351	transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0007077	mitotic nuclear envelope disassembly
GO:0007166	cell surface receptor signaling pathway
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0008645	hexose transport
GO:0009755	hormone-mediated signaling pathway
GO:0009966	regulation of signal transduction
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044281	small molecule metabolic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046578	regulation of Ras protein signal transduction
GO:0051028	mRNA transport
GO:0055085	transmembrane transport

Cellular Component

GO:0000922	spindle pole
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0031074	nucleocytoplasmic shuttling complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0046930	pore complex