InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF5

Summary

InnateDB Protein

IDBP-383613.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF5

Protein Name

activating transcription factor 5

Synonyms

ATFX; HMFN0395;

Species

Homo sapiens

Ensembl Protein

ENSP00000396954

InnateDB Gene

IDBG-63891 (ATF5)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. {ECO:0000269PubMed:10373550, ECO:0000269PubMed:15358120}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15358120}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00978, ECO:0000269PubMed:15358120}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0031072	heat shock protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0021889	olfactory bulb interneuron differentiation
GO:0021891	olfactory bulb interneuron development
GO:0021988	olfactory lobe development
GO:0035264	multicellular organism growth
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048712	negative regulation of astrocyte differentiation
GO:0050768	negative regulation of neurogenesis