InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS4

Summary

InnateDB Protein

IDBP-383615.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS4

Protein Name

transmembrane protease, serine 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000416037

InnateDB Gene

IDBG-73451 (TMPRSS4)

Protein Structure

UniProt Annotation

Function

Probable protease. Seems to be capable of activating ENaC (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09342

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt