Version 5.4
Homo sapiens Gene: TMPRSS4
Summary
InnateDB Gene IDBG-73451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS4
Gene Name transmembrane protease, serine 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137648
Encoded Proteins
IDBP-383615
transmembrane protease, serine 4
IDBP-476219
transmembrane protease, serine 4
IDBP-484397
transmembrane protease, serine 4
IDBP-479876
transmembrane protease, serine 4
IDBP-474182
transmembrane protease, serine 4
IDBP-483361
transmembrane protease, serine 4
IDBP-479101
transmembrane protease, serine 4
IDBP-480062
transmembrane protease, serine 4
IDBP-474296
transmembrane protease, serine 4
IDBP-602773
transmembrane protease, serine 4
IDBP-811657
transmembrane protease, serine 4
IDBP-811659
transmembrane protease, serine 4
IDBP-811664
transmembrane protease, serine 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:118077012-118121890
Strand Forward strand
Band q23.3
Transcripts
ENST00000437212 ENSP00000416037
ENST00000522462
ENST00000519126
ENST00000519236 ENSP00000429889
ENST00000522307 ENSP00000428814
ENST00000523251 ENSP00000429209
ENST00000517483 ENSP00000431062
ENST00000522824 ENSP00000430547
ENST00000522151 ENSP00000428407
ENST00000520063
ENST00000517544 ENSP00000429833
ENST00000519813
ENST00000518610
ENST00000524218 ENSP00000428246
ENST00000523770
ENST00000518413
ENST00000534111 ENSP00000435184
ENST00000528118
ENST00000618855 ENSP00000477949
ENST00000616579 ENSP00000478147
ENST00000610964 ENSP00000480370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0008152 metabolic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032091
View Gene Order
ENSBTAG00000021518
Not yet available
Cross-References
SwissProt
TrEMBL E5RJR8
UniProt Splice Variant
Entrez Gene 56649
UniGene Hs.161985 Hs.669066 Hs.695228
RefSeq NM_001083947 NM_001173551 NM_001173552 NM_001290094 NM_019894
HUGO HGNC:11878
OMIM 606565
CCDS CCDS31684 CCDS44743 CCDS53716 CCDS53717
HPRD 05952
IMGT
EMBL AP000665 AP002800
GenPept
RNA Seq Atlas 56649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca