InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNBP

Summary

InnateDB Protein

IDBP-383694.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNBP

Protein Name

CCHC-type zinc finger, nucleic acid binding protein

Synonyms

CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9;

Species

Homo sapiens

Ensembl Protein

ENSP00000400444

InnateDB Gene

IDBG-55569 (CNBP)

Protein Structure

UniProt Annotation

Function

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Dystrophia myotonica 2 (DM2) [MIM:602668]: A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.

Tissue Specificity

Present in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	48 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006695	cholesterol biosynthetic process
GO:0008284	positive regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter