Version 5.4
Homo sapiens Gene: CNBP
Summary
InnateDB Gene IDBG-55569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNBP
Gene Name CCHC-type zinc finger, nucleic acid binding protein
Synonyms CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
Species Homo sapiens
Ensembl Gene ENSG00000169714
Encoded Proteins
IDBP-383694
CCHC-type zinc finger, nucleic acid binding protein
IDBP-383695
CCHC-type zinc finger, nucleic acid binding protein
IDBP-383696
CCHC-type zinc finger, nucleic acid binding protein
IDBP-383698
CCHC-type zinc finger, nucleic acid binding protein
IDBP-484563
CCHC-type zinc finger, nucleic acid binding protein
IDBP-480863
CCHC-type zinc finger, nucleic acid binding protein
IDBP-484551
CCHC-type zinc finger, nucleic acid binding protein
IDBP-477628
CCHC-type zinc finger, nucleic acid binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:129169484-129183922
Strand Reverse strand
Band q21.3
Transcripts
ENST00000446936 ENSP00000400444
ENST00000422453 ENSP00000410619
ENST00000451728 ENSP00000399488
ENST00000441626 ENSP00000410769
ENST00000502976 ENSP00000421323
ENST00000500450 ENSP00000426223
ENST00000504813 ENSP00000422110
ENST00000502372
ENST00000512338 ENSP00000424787
ENST00000507573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated
Total 50 [view]
Protein-Protein 48 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006695 cholesterol biosynthetic process
GO:0008284 positive regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030057
View Gene Order
ENSBTAG00000012159
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518249
RefSeq NM_001127192 NM_001127193 NM_001127194 NM_001127195 NM_001127196 NM_003418
HUGO
OMIM
CCDS CCDS3056 CCDS46906 CCDS46907 CCDS46908 CCDS54637
HPRD 00311
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca