Version 5.4
Homo sapiens Protein: FBXW8
Summary
InnateDB Protein IDBP-383802.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXW8
Protein Name F-box and WD repeat domain containing 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000389144
InnateDB Gene IDBG-59327 (FBXW8)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269PubMed:18498745, ECO:0000269PubMed:21572988, ECO:0000269PubMed:24362026, ECO:0000269PubMed:24793695}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:21572988}. Golgi apparatus {ECO:0000269PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0007030 Golgi organization
GO:0008283 cell proliferation
GO:0016567 protein ubiquitination
GO:0050775 positive regulation of dendrite morphogenesis
Cellular Component
GO:0005794 Golgi apparatus
GO:0031467 Cul7-RING ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm
GO:1990393 3M complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR001810 F-box domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00320
SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N3Y1
PhosphoSite PhosphoSite-Q8N3Y1
TrEMBL
UniProt Splice Variant
Entrez Gene 26259
UniGene Hs.696428
RefSeq NP_036306
HUGO HGNC:13597
OMIM 609073
CCDS CCDS44988
HPRD 16427
IMGT
EMBL AC026368 AC083806 AC127164 AF176707 BC037296
GenPept AAF03129 AAH37296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca