InnateDB Protein
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IDBP-383849.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GPSM1
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Protein Name
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G-protein signaling modulator 1
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Synonyms
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AGS3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000390705
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InnateDB Gene
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IDBG-92256 (GPSM1)
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Protein Structure
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Function |
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269PubMed:11024022, ECO:0000269PubMed:12642577}.
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Subcellular Localization |
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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Disease Associations |
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Tissue Specificity |
Expressed in intestinal cells. {ECO:0000269PubMed:12642577}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005092
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GDP-dissociation inhibitor activity
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GO:0030695
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GTPase regulator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003109
GoLoco motif
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PFAM |
PF02188
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PRINTS |
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PIRSF |
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SMART |
SM00390
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TIGRFAMs |
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Modification |
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SwissProt |
Q86YR5
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PhosphoSite |
PhosphoSite-Q86YR5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26086
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UniGene |
Hs.595811
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RefSeq |
NP_001139111
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HUGO |
HGNC:17858
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OMIM |
609491
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CCDS |
CCDS48056
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HPRD |
17075
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IMGT |
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EMBL |
AL117478
AY173053
BC009979
BC017353
BC048343
BX649589
CH471090
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GenPept |
AAH09979
AAH17353
AAH48343
AAO17260
CAB55951
CAI19338
CAI19339
CAM27654
EAW88216
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