Version 5.4
Homo sapiens Protein: PMPCA
Summary
InnateDB Protein IDBP-383931.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMPCA
Protein Name peptidase (mitochondrial processing) alpha
Synonyms Alpha-MPP; INPP5E; P-55;
Species Homo sapiens
Ensembl Protein ENSP00000416702
InnateDB Gene IDBG-92370 (PMPCA)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006626 protein targeting to mitochondrion
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR007863 Peptidase M16, C-terminal domain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal
PFAM PF05193
PF00675
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q10713
PhosphoSite PhosphoSite-Q10713
TrEMBL Q9BT52
UniProt Splice Variant
Entrez Gene 23203
UniGene Hs.495471
RefSeq NP_001269875
HUGO HGNC:18667
OMIM 613036
CCDS CCDS65192
HPRD 07500
IMGT
EMBL AK296617 AL592301 BC004342 BC022949 BC033103 BC111399 BC132724 BC136599 CH471090 D21064 D50913
GenPept AAH04342 AAH22949 AAH33103 AAI11400 AAI32725 AAI36600 BAA04643 BAA09472 BAG59225 CAI13945 EAW88232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca