InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAOK3

Summary

InnateDB Protein

IDBP-383970.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAOK3

Protein Name

TAO kinase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000416374

InnateDB Gene

IDBG-59760 (TAOK3)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269PubMed:10559204, ECO:0000269PubMed:10924369, ECO:0000269PubMed:17396146}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:13679851}. Cell membrane {ECO:0000269PubMed:13679851}; Peripheral membrane protein {ECO:0000269PubMed:13679851}. Note=Also localized to the peripheral cell membrane.

Disease Associations

Tissue Specificity

Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. {ECO:0000269PubMed:10924369, ECO:0000269PubMed:13679851}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006974	cellular response to DNA damage stimulus
GO:0016310	phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0043507	positive regulation of JUN kinase activity
GO:0046329	negative regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt