Version 5.4
Homo sapiens Protein: SEC16A
Summary
InnateDB Protein IDBP-384012.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC16A
Protein Name SEC16 homolog A (S. cerevisiae)
Synonyms KIAA0310; p250; SEC16L;
Species Homo sapiens
Ensembl Protein ENSP00000403525
InnateDB Gene IDBG-92412 (SEC16A)
Protein Structure
UniProt Annotation
Function Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. {ECO:0000269PubMed:17005010, ECO:0000269PubMed:17192411}.
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
Disease Associations
Tissue Specificity Ubiquitous. Expressed at higher levels in the pancreas. {ECO:0000269PubMed:17192411}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0048208 COPII vesicle coating
Cellular Component
GO:0000139 Golgi membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-O15027
TrEMBL X6RGP5
UniProt Splice Variant
Entrez Gene 9919
UniGene Hs.602836
RefSeq XP_005266193
HUGO HGNC:29006
OMIM 612854
CCDS
HPRD
IMGT
EMBL AK301371 AK316194 AL592301
GenPept BAG62913 BAH14565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca