Version 5.4
Homo sapiens Protein: VGF
Summary
InnateDB Protein IDBP-384131.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VGF
Protein Name VGF nerve growth factor inducible
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000400884
InnateDB Gene IDBG-33066 (VGF)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. {ECO:0000250}.NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release.Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
Subcellular Localization Secreted {ECO:0000269PubMed:19194657}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269PubMed:19194657}. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
Disease Associations
Tissue Specificity Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. {ECO:0000269PubMed:19194657}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008083 growth factor activity
Biological Process
GO:0042742 defense response to bacterium
GO:0051591 response to cAMP
Cellular Component
GO:0005615 extracellular space
GO:0030133 transport vesicle
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15240
PhosphoSite PhosphoSite-O15240
TrEMBL
UniProt Splice Variant
Entrez Gene 7425
UniGene Hs.587325
RefSeq XP_005250618
HUGO HGNC:12684
OMIM 602186
CCDS CCDS5712
HPRD 03717
IMGT
EMBL AC004876 BC063835 CH471197 Y12661
GenPept AAD45830 AAH63835 CAA73210 EAW50201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca