InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SENP6

Summary

InnateDB Protein

IDBP-384180.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SENP6

Protein Name

SUMO1/sentrin specific peptidase 6

Synonyms

SSP1; SUSP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000402527

InnateDB Gene

IDBG-93129 (SENP6)

Protein Structure

UniProt Annotation

Function

Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269PubMed:16912044, ECO:0000269PubMed:17000875, ECO:0000269PubMed:18799455, ECO:0000269PubMed:20212317, ECO:0000269PubMed:20705237, ECO:0000269PubMed:21148299}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16912044, ECO:0000269PubMed:17000875}.

Disease Associations

Tissue Specificity

Highly expressed in reproductive organs, such as testis, ovary and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016929	SUMO-specific protease activity

Biological Process

GO:0006508	proteolysis
GO:0016925	protein sumoylation
GO:0016926	protein desumoylation
GO:0070646	protein modification by small protein removal
GO:0090169	regulation of spindle assembly
GO:0090234	regulation of kinetochore assembly