Version 5.4
| Homo sapiens Gene: SENP6 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-93129.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SENP6 | ||||||||||||||||||
| Gene Name | SUMO1/sentrin specific peptidase 6 | ||||||||||||||||||
| Synonyms | SSP1; SUSP1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000112701 | ||||||||||||||||||
| Encoded Proteins |
SUMO1/sentrin specific peptidase 6
SUMO1/sentrin specific peptidase 6
SUMO1/sentrin specific peptidase 6
SUMO1/sentrin specific peptidase 6
SUMO1/sentrin specific peptidase 6
SUMO1/sentrin specific peptidase 6
SUMO1/sentrin specific peptidase 6
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:75601509-75718278 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q14.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | D6RJH1 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 26054 | ||||||||||||||||||
| UniGene | Hs.485784 Hs.627115 | ||||||||||||||||||
| RefSeq | NM_001100409 NM_015571 XM_006715457 | ||||||||||||||||||
| HUGO | HGNC:20944 | ||||||||||||||||||
| OMIM | 605003 | ||||||||||||||||||
| CCDS | CCDS43483 CCDS47454 | ||||||||||||||||||
| HPRD | 05417 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL109897 AL355797 AL356057 AL589656 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 26054 | ||||||||||||||||||