InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSD17B4

Summary

InnateDB Protein

IDBP-38419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B4

Protein Name

hydroxysteroid (17-beta) dehydrogenase 4

Synonyms

DBP; MFE-2; MPF-2; PRLTS1; SDR8C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000256216

InnateDB Gene

IDBG-38417 (HSD17B4)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids. {ECO:0000269PubMed:8902629, ECO:0000269PubMed:9089413}.

Subcellular Localization

Peroxisome.

Disease Associations

D-bifunctional protein deficiency (DBPD) [MIM:261515]: Disorder of peroxisomal fatty acid beta-oxidation. {ECO:0000269PubMed:10400999, ECO:0000269PubMed:11743515, ECO:0000269PubMed:9482850}. Note=The disease is caused by mutations affecting the gene represented in this entry.Perrault syndrome 1 (PRLTS1) [MIM:233400]: A sex- influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement. {ECO:0000269PubMed:20673864}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Present in many tissues with highest concentrations in liver, heart, prostate and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	28 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0016508	long-chain-enoyl-CoA hydratase activity
GO:0016853	isomerase activity
GO:0033989	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
GO:0042803	protein homodimerization activity
GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006635	fatty acid beta-oxidation
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0008206	bile acid metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0036111	very long-chain fatty-acyl-CoA metabolic process
GO:0036112	medium-chain fatty-acyl-CoA metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002539 MaoC-like domain
IPR003033 SCP2 sterol-binding domain
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR
IPR029069 HotDog domain

PFAM

PF00106
PF01575
PF02036
PF08659

PRINTS

PR00080
PR00081
PR01397

PIRSF

PIRSF000126

SMART

SM00822

TIGRFAMs

Post-translational Modifications

Modification

Cross-References