Version 5.4
Homo sapiens Protein: SLC16A5
Summary
InnateDB Protein IDBP-384255.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC16A5
Protein Name solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
Synonyms MCT5; MCT6;
Species Homo sapiens
Ensembl Protein ENSP00000390564
InnateDB Gene IDBG-67985 (SLC16A5)
Protein Structure
UniProt Annotation
Function Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Highly expressed in kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
Biological Process
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15375
PhosphoSite PhosphoSite-O15375
TrEMBL J3QQW5
UniProt Splice Variant
Entrez Gene 9121
UniGene Hs.592095
RefSeq XP_006722233
HUGO HGNC:10926
OMIM 603879
CCDS CCDS11713
HPRD 04856
IMGT
EMBL AC111186 BC009684 BC033611 CH471099 U59299
GenPept AAC52013 AAH09684 AAH33611 EAW89233 EAW89234 EAW89235

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca