Version 5.4
Homo sapiens Protein: NRGN
Summary
InnateDB Protein IDBP-384319.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRGN
Protein Name neurogranin (protein kinase C substrate, RC3)
Synonyms hng; RC3;
Species Homo sapiens
Ensembl Protein ENSP00000399591
InnateDB Gene IDBG-75248 (NRGN)
Protein Structure
UniProt Annotation
Function Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. {ECO:0000269PubMed:9329454}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0007165 signal transduction
GO:0007399 nervous system development
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
PFAM PF00612
PRINTS
PIRSF
SMART SM00015
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92686
PhosphoSite PhosphoSite-Q92686
TrEMBL A0A024R3M7
UniProt Splice Variant
Entrez Gene 4900
UniGene Hs.722314
RefSeq
HUGO HGNC:8000
OMIM 602350
CCDS CCDS8451
HPRD 03828
IMGT
EMBL AJ317956 BC002835 BT007325 CH471065 U89165 X99075 X99076 Y09689 Y15058 Y15059
GenPept AAB49458 AAH02835 AAP35989 CAA67533 CAA70867 CAA75343 CAC37631 EAW67593 EAW67594

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca