InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASA4

Summary

InnateDB Protein

IDBP-384385.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASA4

Protein Name

RAS p21 protein activator 4

Synonyms

CAPRI; GAPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000412876

InnateDB Gene

IDBG-33794 (RASA4)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269PubMed:11448776}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:11448776}. Cell membrane {ECO:0000269PubMed:11448776}; Peripheral membrane protein {ECO:0000269PubMed:11448776}. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11448776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction