Version 5.4
Homo sapiens Protein: SMPD3
Summary
InnateDB Protein IDBP-38449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPD3
Protein Name sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000219334
InnateDB Gene IDBG-38447 (SMPD3)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269PubMed:10823942, ECO:0000269PubMed:14741383, ECO:0000269PubMed:15051724}.
Subcellular Localization Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Disease Associations
Tissue Specificity Predominantly expressed in brain. {ECO:0000269PubMed:10823942}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006665 sphingolipid metabolic process
GO:0006684 sphingomyelin metabolic process
GO:0006685 sphingomyelin catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0007049 cell cycle
GO:0007275 multicellular organismal development
GO:0030072 peptide hormone secretion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NY59
PhosphoSite PhosphoSite-Q9NY59
TrEMBL H3BTM0
UniProt Splice Variant
Entrez Gene 55512
UniGene Hs.735133
RefSeq NP_061137
HUGO HGNC:14240
OMIM 605777
CCDS CCDS10867
HPRD 16154
IMGT
EMBL AC099521 AJ250460 BC112238 BC143631 GQ404557 GU992201 GU992202
GenPept AAI12239 AAI43632 ACV30039 ADG64729 ADG64730 CAB92964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca