Version 5.4
Homo sapiens Gene: SMPD3
Summary
InnateDB Gene IDBG-38447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPD3
Gene Name sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103056
Encoded Proteins
IDBP-38449
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
IDBP-752262
IDBP-752807
IDBP-751275
IDBP-749194
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68358325-68448688
Strand Reverse strand
Band q22.1
Transcripts
ENST00000219334 ENSP00000219334
ENST00000561749 ENSP00000457236
ENST00000574662 ENSP00000459317
ENST00000567811
ENST00000563226 ENSP00000455955
ENST00000566009
ENST00000566466
ENST00000567223
ENST00000563396
ENST00000568373 ENSP00000457422
ENST00000563455
ENST00000566723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006665 sphingolipid metabolic process
GO:0006684 sphingomyelin metabolic process
GO:0006685 sphingomyelin catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0007049 cell cycle
GO:0007275 multicellular organismal development
GO:0030072 peptide hormone secretion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031906
View Gene Order
ENSBTAG00000009639
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
Cross-References
SwissProt Q9NY59
TrEMBL C8CHW6 H3BTM0
UniProt Splice Variant
Entrez Gene 55512
UniGene Hs.368421 Hs.735133
RefSeq NM_018667 XM_005256031 XM_005256032 XM_006721230
HUGO HGNC:14240
OMIM 605777
CCDS CCDS10867
HPRD 16154
IMGT
EMBL AC099521 AJ250460 BC112238 BC143631 GQ404557
GenPept AAI12239 AAI43632 ACV30039 CAB92964
RNA Seq Atlas 102724538 55512

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca