InnateDB Protein
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IDBP-384494.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NAPEPLD
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Protein Name
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N-acyl phosphatidylethanolamine phospholipase D
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000412376
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InnateDB Gene
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IDBG-34189 (NAPEPLD)
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Protein Structure
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Function |
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008270
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zinc ion binding
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GO:0070290
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N-acylphosphatidylethanolamine-specific phospholipase D activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001279
Beta-lactamase-like
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PFAM |
PF00753
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PRINTS |
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PIRSF |
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SMART |
SM00849
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TIGRFAMs |
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Modification |
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SwissProt |
Q6IQ20
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PhosphoSite |
PhosphoSite-Q6IQ20
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TrEMBL |
J3KR15
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UniProt Splice Variant |
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Entrez Gene |
222236
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UniGene |
Hs.707586
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RefSeq |
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HUGO |
HGNC:21683
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OMIM |
612334
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CCDS |
CCDS5729
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HPRD |
14809
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IMGT |
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EMBL |
AB112352
AC007683
AY357337
BC071604
CH471070
CR936639
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GenPept |
AAH71604
AAR13673
BAD02399
CAI56779
EAW83314
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