InnateDB Protein
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IDBP-384633.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BCL2L11
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Protein Name
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BCL2-like 11 (apoptosis facilitator)
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Synonyms
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BAM; BIM; BOD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403727
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InnateDB Gene
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IDBG-65821 (BCL2L11)
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Protein Structure
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Function |
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269PubMed:11997495, ECO:0000269PubMed:15486195, ECO:0000269PubMed:9430630}.
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Subcellular Localization |
Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell adherence.Isoform BimL: Mitochondrion.Isoform BimS: Mitochondrion.Isoform Bim-alpha1: Mitochondrion.
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Disease Associations |
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Tissue Specificity |
Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. {ECO:0000269PubMed:12019181}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
81
[view]
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Protein-Protein |
77
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0006915
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apoptotic process
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0008630
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intrinsic apoptotic signaling pathway in response to DNA damage
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GO:0032464
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positive regulation of protein homooligomerization
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GO:0034976
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response to endoplasmic reticulum stress
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GO:0043065
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positive regulation of apoptotic process
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0090200
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positive regulation of release of cytochrome c from mitochondria
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GO:0097190
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apoptotic signaling pathway
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GO:0097193
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intrinsic apoptotic signaling pathway
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GO:1900740
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positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
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GO:2000271
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positive regulation of fibroblast apoptotic process
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GO:2001244
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positive regulation of intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR014771
Apoptosis, Bim N-terminal
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PFAM |
PF06773
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43521
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PhosphoSite |
PhosphoSite-O43521
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TrEMBL |
E9PAM9
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UniProt Splice Variant |
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Entrez Gene |
10018
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UniGene |
Hs.737004
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RefSeq |
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HUGO |
HGNC:994
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OMIM |
603827
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CCDS |
CCDS56136
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HPRD |
04828
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IMGT |
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EMBL |
AB071195
AB071196
AB071197
AB071198
AB071199
AB071200
AC096670
AF032457
AF032458
AK290377
AK291269
AY305714
AY305715
AY352518
AY423441
AY423442
AY423443
AY428962
BC033694
CH471237
DQ849200
DQ849201
DQ849202
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GenPept |
AAC39593
AAC39594
AAH33694
AAQ62569
AAQ82546
AAQ82547
AAQ99148
AAQ99149
AAQ99150
AAR06908
AAY14797
ABI13589
ABI13590
ABI13591
BAB78589
BAB78590
BAB78591
BAB78592
BAB78593
BAB78594
BAF83066
BAF83958
EAW50365
EAW50367
EAW50369
EAW50370
EAW50371
EAW50372
EAW50373
EAW50374
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