InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL2L11

Summary

InnateDB Protein

IDBP-384635.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L11

Protein Name

BCL2-like 11 (apoptosis facilitator)

Synonyms

BAM; BIM; BOD;

Species

Homo sapiens

Ensembl Protein

ENSP00000391292

InnateDB Gene

IDBG-65821 (BCL2L11)

Protein Structure

UniProt Annotation

Function

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. {ECO:0000269PubMed:11997495, ECO:0000269PubMed:15486195, ECO:0000269PubMed:9430630}.

Subcellular Localization

Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with intracytoplasmic membranes. {ECO:0000250}.Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell adherence.Isoform BimL: Mitochondrion.Isoform BimS: Mitochondrion.Isoform Bim-alpha1: Mitochondrion.

Disease Associations

Tissue Specificity

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. {ECO:0000269PubMed:12019181}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	77 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032464	positive regulation of protein homooligomerization
GO:0034976	response to endoplasmic reticulum stress
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000271	positive regulation of fibroblast apoptotic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0005874	microtubule
GO:0012505	endomembrane system
GO:0097140	BIM-BCL-xl complex
GO:0097141	BIM-BCL-2 complex