InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR1B

Summary

InnateDB Protein

IDBP-384787.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR1B

Protein Name

polymerase (RNA) I polypeptide B, 128kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000405358

InnateDB Gene

IDBG-66306 (POLR1B)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:11250903}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0032549	ribonucleoside binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6
IPR007641 RNA polymerase Rpb2, domain 7
IPR007642 RNA polymerase Rpb2, domain 2
IPR007644 RNA polymerase, beta subunit, protrusion
IPR007645 RNA polymerase Rpb2, domain 3
IPR007647 RNA polymerase Rpb2, domain 5
IPR009674 RNA polymerase I, Rpa2 specific

PFAM