Version 5.4
Homo sapiens Protein: LILRA5
Summary
InnateDB Protein IDBP-384838.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LILRA5
Protein Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000404236
InnateDB Gene IDBG-68498 (LILRA5)
Protein Structure
UniProt Annotation
Function May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. {ECO:0000269PubMed:16675463}.
Subcellular Localization Isoform 1: Membrane; Single-pass type I membrane protein. Secreted.Isoform 2: Membrane; Single-pass type I membrane protein. Secreted.Isoform 3: Secreted.Isoform 4: Secreted.
Disease Associations
Tissue Specificity Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level). {ECO:0000269PubMed:12393390}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
PFAM
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NI73
PhosphoSite PhosphoSite-A6NI73
TrEMBL
UniProt Splice Variant
Entrez Gene 353514
UniGene Hs.710986
RefSeq NP_067073
HUGO HGNC:16309
OMIM 606047
CCDS CCDS12888
HPRD 06924
IMGT
EMBL AC008984 AF212842 AF324830 AF499916 AF499917 AF499918 AF499919 CH471135
GenPept AAF73849 AAK52451 AAN27925 AAN27926 AAN27927 AAN27928 EAW72226 EAW72227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca