InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLRP2

Summary

InnateDB Protein

IDBP-385196.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLRP2

Protein Name

NLR family, pyrin domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000402474

InnateDB Gene

IDBG-69883 (NLRP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0032090	Pyrin domain binding

Biological Process

GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0050718	positive regulation of interleukin-1 beta secretion

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NX02

PhosphoSite