Version 5.4
Homo sapiens Gene: NLRP2
Summary
InnateDB Gene IDBG-69883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRP2
Gene Name NLR family, pyrin domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000022556
Encoded Proteins
IDBP-764304
IDBP-69885
NLR family, pyrin domain containing 2
IDBP-69887
NLR family, pyrin domain containing 2
IDBP-590178
NLR family, pyrin domain containing 2
IDBP-247122
NLR family, pyrin domain containing 2
IDBP-385196
NLR family, pyrin domain containing 2
IDBP-385222
NLR family, pyrin domain containing 2
IDBP-590031
NLR family, pyrin domain containing 2
IDBP-603419
NLR family, pyrin domain containing 2
IDBP-603957
NLR family, pyrin domain containing 2
IDBP-765488
IDBP-583483
NLR family, pyrin domain containing 2
IDBP-584840
NLR family, pyrin domain containing 2
IDBP-765879
IDBP-761359
IDBP-765735
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18056399
NLRP2 is an inhibitor of the NF-kappaB pathway.
PMID 15030775
NLRP2 associates with PYCARD, RIPK2, and CASP1, forming an inflammasome with high proIL-1beta-processing activity.
Entrez Gene
Summary NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54953130-55001142
Strand Forward strand
Band q13.42
Transcripts
ENST00000381637 ENSP00000469973
ENST00000263437 ENSP00000263437
ENST00000339757 ENSP00000344074
ENST00000397169 ENSP00000441363
ENST00000391721 ENSP00000375601
ENST00000427260 ENSP00000402474
ENST00000448584 ENSP00000409370
ENST00000433772 ENSP00000443519
ENST00000543010 ENSP00000445135
ENST00000540597
ENST00000539848 ENSP00000442351
ENST00000540005 ENSP00000466537
ENST00000543277 ENSP00000445846
ENST00000542755
ENST00000537859 ENSP00000440601
ENST00000586512
ENST00000588619 ENSP00000466260
ENST00000588107 ENSP00000465069
ENST00000585500 ENSP00000467349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0032090 Pyrin domain binding
Biological Process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0050718 positive regulation of interleukin-1 beta secretion
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9NX02
TrEMBL F5H7Q5 K7EJ90
UniProt Splice Variant
Entrez Gene 55655
UniGene Hs.369279 Hs.597119
RefSeq NM_001174082 NM_001174081 NM_001174083 NM_017852
HUGO HGNC:22948
OMIM 609364
CCDS CCDS54319 CCDS12913 CCDS54318
HPRD 14805
IMGT
EMBL AB209300 AC011476 AF298547 AF310106 AF464764 AK000517 AK000784 AK025952 AK223253 AK223269 AK302989 BC001039 BC003592 BC039269
GenPept AAG15253 AAG30289 AAH01039 AAH03592 AAH39269 AAL69962 BAA91223 BAA91377 BAB15293 BAD92537 BAD96973 BAD96989 BAG64129
RNA Seq Atlas 55655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca