Version 5.4
Homo sapiens Protein: GABRR1
Summary
InnateDB Protein IDBP-385241.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRR1
Protein Name gamma-aminobutyric acid (GABA) receptor, rho 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000412673
InnateDB Gene IDBG-94299 (GABRR1)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Highly expressed in the retina and in a lesser extent in brain, lung and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008057 Gamma-aminobutyric-acid A receptor, Rho
IPR008058 Gamma-aminobutyric-acid A receptor, Rho1
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01670
PR01671
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P24046
PhosphoSite PhosphoSite-P24046
TrEMBL
UniProt Splice Variant
Entrez Gene 2569
UniGene Hs.99927
RefSeq NP_002033
HUGO HGNC:4090
OMIM 137161
CCDS CCDS5019
HPRD 15921
IMGT
EMBL AK296124 AK298948 AL353135 AL353659 BC130344 M62400
GenPept AAA52509 AAI30345 BAG58870 BAG61047 CAC36328 CAI16246

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca