Version 5.4
Homo sapiens Gene: GABRR1
Summary
InnateDB Gene IDBG-94299.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRR1
Gene Name gamma-aminobutyric acid (GABA) A receptor, rho 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146276
Encoded Proteins
IDBP-94301
gamma-aminobutyric acid (GABA) receptor, rho 1
IDBP-385241
gamma-aminobutyric acid (GABA) receptor, rho 1
IDBP-385242
gamma-aminobutyric acid (GABA) receptor, rho 1
IDBP-385256
gamma-aminobutyric acid (GABA) receptor, rho 1
IDBP-813644
gamma-aminobutyric acid (GABA) A receptor, rho 1
IDBP-813645
gamma-aminobutyric acid (GABA) A receptor, rho 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:89177501-89231278
Strand Reverse strand
Band q15
Transcripts
ENST00000369451 ENSP00000358463
ENST00000454853 ENSP00000412673
ENST00000435811 ENSP00000394687
ENST00000457434 ENSP00000410130
ENST00000481493
ENST00000611484 ENSP00000478846
ENST00000621627 ENSP00000481986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028280
View Gene Order
ENSBTAG00000011672
Not yet available
Pathways
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_25168
GABA A (rho) receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2569
UniGene
RefSeq NM_001256704 NM_001256703 NM_001267582 NM_002042 XM_006715438
HUGO HGNC:4090
OMIM 137161
CCDS CCDS59028 CCDS5019 CCDS59029
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 2569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca