InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOCK4

Summary

InnateDB Protein

IDBP-385325.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK4

Protein Name

dedicator of cytokinesis 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000404179

InnateDB Gene

IDBG-36595 (DOCK4)

Protein Structure

UniProt Annotation

Function

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. {ECO:0000269PubMed:12628187, ECO:0000269PubMed:20679435}.

Subcellular Localization

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytosol.

Disease Associations

Tissue Specificity

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. {ECO:0000269PubMed:12628187}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0030165	PDZ domain binding
GO:0030675	Rac GTPase activator activity
GO:0030971	receptor tyrosine kinase binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0060326	cell chemotaxis

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0032420	stereocilium
GO:0032421	stereocilium bundle

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR001452 SH3 domain
IPR008936 Rho GTPase activation protein
IPR010703 Dedicator of cytokinesis C-terminal
IPR011511 Variant SH3 domain

PFAM

PF00168
PF00018
PF14604
PF06920
PF07653

PRINTS

PR00360
PR00452

PIRSF

SMART

SM00239
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt