InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BACE2

Summary

InnateDB Protein

IDBP-3854.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BACE2

Protein Name

beta-site APP-cleaving enzyme 2

Synonyms

AEPLC; ALP56; ASP1; ASP21; BAE2; CEAP1; DRAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000332979

InnateDB Gene

IDBG-3852 (BACE2)

Protein Structure

UniProt Annotation

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. {ECO:0000269PubMed:10591213, ECO:0000269PubMed:11083922, ECO:0000269PubMed:11423558, ECO:0000269PubMed:15857888, ECO:0000269PubMed:16816112}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.

Disease Associations

Tissue Specificity

Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. {ECO:0000269PubMed:10591213, ECO:0000269PubMed:10677483, ECO:0000269PubMed:10683441, ECO:0000269PubMed:10749877, ECO:0000269PubMed:10838186, ECO:0000269PubMed:10965118, ECO:0000269PubMed:11083922}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0016486	peptide hormone processing
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process

Cellular Component

GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001461 Aspartic peptidase
IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR009121 Peptidase A1, beta-site APP cleaving enzyme 2, BACE 2
IPR021109 Aspartic peptidase domain

PFAM

PF00026

PRINTS

PR00792
PR01815
PR01816
PR01817

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5Z0