InnateDB Protein
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IDBP-38542.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WDR82
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Protein Name
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WD repeat domain 82
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000296490
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InnateDB Gene
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IDBG-38540 (WDR82)
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Protein Structure
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Function |
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269PubMed:17998332, ECO:0000269PubMed:18838538, ECO:0000269PubMed:20516061}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16253997, ECO:0000269PubMed:17355966, ECO:0000269PubMed:20516061}. Note=Associates with chromatin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
62
[view]
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Protein-Protein |
62
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
IPR020472
G-protein beta WD-40 repeat
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PFAM |
PF00400
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PRINTS |
PR00320
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UXN9
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PhosphoSite |
PhosphoSite-Q6UXN9
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TrEMBL |
C9JBU3
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UniProt Splice Variant |
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Entrez Gene |
80335
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UniGene |
Hs.717997
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RefSeq |
NP_079498
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HUGO |
HGNC:28826
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OMIM |
611059
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CCDS |
CCDS2851
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HPRD |
15183
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IMGT |
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EMBL |
AC092045
AK074290
AK291380
AY358264
CH471055
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GenPept |
AAQ88631
BAB85039
BAF84069
EAW65202
EAW65203
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