InnateDB Protein
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IDBP-385454.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNFSF10
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Protein Name
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tumor necrosis factor (ligand) superfamily, member 10
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Synonyms
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Apo-2L; APO2L; CD253; TL2; TRAIL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389931
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InnateDB Gene
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IDBG-65161 (TNFSF10)
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Protein Structure
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Function |
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widespread; most predominant in spleen, lung and prostate.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
52
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
26
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006915
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apoptotic process
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0006955
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immune response
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GO:0007165
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signal transduction
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GO:0007267
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cell-cell signaling
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GO:0043065
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positive regulation of apoptotic process
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0043280
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positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0090200
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positive regulation of release of cytochrome c from mitochondria
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GO:0097190
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apoptotic signaling pathway
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GO:2001238
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positive regulation of extrinsic apoptotic signaling pathway
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GO:2001239
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regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P50591
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PhosphoSite |
PhosphoSite-P50591
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TrEMBL |
Q6JSD9
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UniProt Splice Variant |
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Entrez Gene |
8743
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UniGene |
Hs.619712
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RefSeq |
NP_001177871
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HUGO |
HGNC:11925
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OMIM |
603598
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CCDS |
CCDS54680
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HPRD |
04670
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IMGT |
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EMBL |
AC007919
AC016938
AK296085
AY312579
BC032722
DQ848564
EU183231
U37518
U57059
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GenPept |
AAB01233
AAC50332
AAH32722
AAR16184
ABI24016
ABW24658
BAG58840
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