InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFSF10

Summary

InnateDB Gene

IDBG-65161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF10

Gene Name

tumor necrosis factor (ligand) superfamily, member 10

Synonyms

Apo-2L; APO2L; CD253; TL2; TRAIL

Species

Homo sapiens

Ensembl Gene

ENSG00000121858

Encoded Proteins

IDBP-65163

tumor necrosis factor (ligand) superfamily, member 10

IDBP-385454

tumor necrosis factor (ligand) superfamily, member 10

IDBP-385455

tumor necrosis factor (ligand) superfamily, member 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23498957

TNFSF10 is targeted by human cytomegalovirus glycoprotein to protect infected cells from natural killer cell cytotoxicity.

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:172505508-172523507

Strand

Reverse strand

Band

q26.31

Transcripts

ENST00000241261	ENSP00000241261
ENST00000420541	ENSP00000389931
ENST00000430881	ENSP00000404008
ENST00000494851
ENST00000472804
ENST00000466777

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.

Experimentally validated
Total	52 [view]
Protein-Protein	26 [view]
Protein-DNA	26 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008584	male gonad development
GO:0032868	response to insulin
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome