InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBL1XR1

Summary

InnateDB Protein

IDBP-385535.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBL1XR1

Protein Name

transducin (beta)-like 1 X-linked receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000413251

InnateDB Gene

IDBG-65899 (TBL1XR1)

Protein Structure

UniProt Annotation

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. {ECO:0000269PubMed:14980219}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0016568	chromatin modification
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005876	spindle microtubule
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR006594 LisH dimerisation motif
IPR013720 LisH dimerisation motif, subgroup
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08513

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt