Version 5.4
Homo sapiens Protein: CSTF3
Summary
InnateDB Protein IDBP-38558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSTF3
Protein Name cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
Synonyms CSTF-77;
Species Homo sapiens
Ensembl Protein ENSP00000315791
InnateDB Gene IDBG-38556 (CSTF3)
Protein Structure
UniProt Annotation
Function One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 26 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006378 mRNA polyadenylation
GO:0006379 mRNA cleavage
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003107 HAT (Half-A-TPR) repeat
IPR008847 Suppressor of forked
PFAM PF02184
PF05843
PRINTS
PIRSF
SMART SM00386
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12996
PhosphoSite PhosphoSite-Q12996
TrEMBL E9PJ06
UniProt Splice Variant
Entrez Gene 1479
UniGene Hs.626383
RefSeq NP_001317
HUGO HGNC:2485
OMIM 600367
CCDS CCDS7883
HPRD 02651
IMGT
EMBL AC131263 AK290836 AL121926 BC009792 BC010533 BC059948 BC108319 BM014288 CH471064 U15782
GenPept AAA61417 AAH09792 AAH10533 AAH59948 AAI08320 BAF83525 CAC48252 EAW68200 EAW68201 EAW68202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca