InnateDB Protein
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IDBP-385844.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HTR3D
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Protein Name
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5-hydroxytryptamine (serotonin) receptor 3 family member D
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389268
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InnateDB Gene
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IDBG-67294 (HTR3D)
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Protein Structure
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Function |
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:17392525}; Multi-pass membrane protein {ECO:0000269PubMed:17392525}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, as well as fetal and adult colon and kidney. {ECO:0000269PubMed:12801637}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005230
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extracellular ligand-gated ion channel activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006029
Neurotransmitter-gated ion-channel transmembrane domain
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PFAM |
PF02932
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q70Z44
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PhosphoSite |
PhosphoSite-Q70Z44
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
200909
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UniGene |
Hs.448004
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RefSeq |
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HUGO |
HGNC:24004
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OMIM |
610122
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CCDS |
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HPRD |
17121
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IMGT |
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EMBL |
AC068644
AC131235
AJ437318
AY159812
BC101090
BC101091
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GenPept |
AAI01091
AAI01092
AAO38166
CAD24817
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