InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACADM

Summary

InnateDB Protein

IDBP-385919.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACADM

Protein Name

acyl-CoA dehydrogenase, C-4 to C-12 straight chain

Synonyms

ACAD1; MCAD; MCADH;

Species

Homo sapiens

Ensembl Protein

ENSP00000409612

InnateDB Gene

IDBG-99766 (ACADM)

Protein Structure

UniProt Annotation

Function

This enzyme is specific for acyl chain lengths of 4 to 16.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Acyl-CoA dehydrogenase medium-chain deficiency (ACADMD) [MIM:201450]: An inborn error of mitochondrial fatty acid beta- oxidation which causes fasting hypoglycemia, hepatic dysfunction and encephalopathy, often resulting in death in infancy. {ECO:0000269PubMed:10767181, ECO:0000269PubMed:11349232, ECO:0000269PubMed:11409868, ECO:0000269PubMed:11486912, ECO:0000269PubMed:1671131, ECO:0000269PubMed:1684086, ECO:0000269PubMed:1902818, ECO:0000269PubMed:2251268, ECO:0000269PubMed:2393404, ECO:0000269PubMed:2394825, ECO:0000269PubMed:7603790, ECO:0000269PubMed:7929823, ECO:0000269PubMed:8198141, ECO:0000269PubMed:9158144}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802	identical protein binding
GO:0050660	flavin adenine dinucleotide binding
GO:0070991	medium-chain-acyl-CoA dehydrogenase activity

Biological Process

GO:0006635	fatty acid beta-oxidation
GO:0008152	metabolic process
GO:0019254	carnitine metabolic process, CoA-linked
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045329	carnitine biosynthetic process
GO:0051791	medium-chain fatty acid metabolic process
GO:0051793	medium-chain fatty acid catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0030424	axon
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR013107 Acyl-CoA dehydrogenase, C-terminal domain
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

PFAM

PF02770
PF00441
PF08028
PF02771

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11310

PhosphoSite